2. Food service staff: Food service staff or the waiter’s job comes next in the most depressing career list as 10 percent of staffs in general reported an episode of major depression in the last year. This is a profession where usually people get a low pay, moreover it is quite a tiring job with different people directing you what to do each day. Deborah says it is quite a thankless job, apart from that, people can be quite rude to you and also there is lot of physical exertion associated with this field of work.